Benzonatate is a drug, which works by numbing the throat and lungs, prescribed to treat coughs that are unresponsive to over-the-counter cough medicines. Last updated on May 26, 2022. Catalog No. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. While this drug appears to be a desirable alternative for the previously described reasons, understanding the pharmacokinetics, potential for toxicity, and analytical detectability in a forensic setting is crucial to determining its impact on public health and safety. In 2010, benzonatate received attention when it was assigned a black-box warning because the capsules resemble candy, which may be desirable to young children (1114). Benzonatate relieves cough by acting directly on the lungs and the breathing passages. Speak to your doctor about how drug interactions should be managed. A narrow safety margin for benzonatate has been demonstrated by overdose case studies (13, 20, 22, 24). Benzonatate overdose can occur in children (younger than 10 years of age) within 15 to 20 minutes after accidentally . Coughing can be very disruptive to work and to sleep, and patients can be desperate for relief. Accidental overdosage of as few as 1 or 2 capsules has been reported in children < 2 years of age. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. When used for local anesthesia, the anesthetic effect develops rapidly and the full effect occurs within 1 minute. Can you use Benzonatate after the expiration date on the bottle? For pregnant women: Benzonatate is a category C pregnancy drug. Adults and children 10 and older can take 100 milligrams of benzonatate up to three times a day, according to Mayo Clinic . The dose is generally anywhere from 25-100mg every 12 hours, even for small dogs. Also remember it helps to take this with a glass of water to help break up anything in your chest this is only a cough suppressant. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Benzonatate is a prescription drug approved for relief of cough in patients over 10 years of age. Benzonatate capsules are to be swallowed whole and are not to be broken, chewed, dissolved, or crushed. U.S. Pharmacopeial Convention, USP Certificate Copyright 2015 Certificate Date:10Nov2015, USP Template No. The maximum dosage is 600 mg per day. Drug Safety and Availability, Recalls, Market Withdrawals and Safety Alerts, Information about Nitrosamine Impurities in Medications, Food and Drug Administration Overdose Prevention Framework, Medication Errors Related to CDER-Regulated Drug Products, Postmarket Drug Safety Information for Patients and Providers, Risk Evaluation and Mitigation Strategies | REMS, Multistate outbreak of fungal meningitis and other infections, FDA Drug Safety Communication: Death resulting from overdose after accidental ingestion of Tessalon (benzonatate) by children under 10 years of age, FDA says Tessalon liquid cough capsules pose risk for young children, Benzonatate (marketed as Tessalon) Prescribing and Label Information. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Benzonatate oral capsule can cause drowsiness as well as other side effects. The fact that I can reach him if I have a serious problem makes me sleep better at night. Copyright 2022 Scripps Media, Inc. All rights reserved. Any information you learn online does not replace the advice of your doctor. Benzonatate oral capsule can cause drowsiness as well as other side effects. The .gov means its official.Federal government websites often end in .gov or .mil. Generic drugs usually cost less. (Links to The Medical Letter review and the FDA warning are below.). Good luck. (. You can also get it through contact with, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Im certainly sympathetic to the miserable patient with a cold or bronchitis who has a terrible cough. Nortriptyline belongs to a class of drugs called tricyclic. Research in animals has shown adverse effects to the fetus when the mother takes the drug. Can ChatGPT write a Jewish Journal column. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Seek medical attention if it does not resolve. How dangerous would it be for either a 5 lb. It is usually taken three times a day as needed. Benzonatate comes as a liquid-filled capsule and a capsule to take by mouth. Accidental death has occurred in children under 10 years old. Its major side effects are nausea, abdominal discomfort, and photosensitivity. Even more challenging is the rapid metabolism of the series of n-ethoxy parent compounds without a suitable pure standard available for quantitation of each specific molecular weight. When a therapeutic dose, administered as a single capsule, is chewed or crushed, there is potential for bronchospasm, laryngospasm, seizures and cardiovascular collapse which mimics the systemic toxicity seen at high doses (6, 15, 19, 20). The safety and effectiveness of benzonatate in children below the age of 10 years have not been established. Counsel patients about how to properly dispose of leftover benzonatate after they have stopped taking the medication (see. Benzonatate may be attractive to children because of the drug's appearance (it is a round-shaped liquid-filled gelatin capsule). McLawhorn et al. Honey can help thin mucus and decrease your cough. other medications that may also upset the gastrointestinal tract, such as prednisone or NSAIDs (such as ibuprofen or naproxen). Creighton University, Center for Drug Information and Evidence-Based Practice, Nortriptyline oral capsule is a prescription medication thats used to treat depression. Im a doctor, but Im not your doctor despite the fact that you read or comment on my posts. Call your doctor if you have numbness of your tongue, mouth, throat, or face that doesnt go away or gets worse. (2015, December). (, Yoshioka, I., Surmaitis, R., Katz, K.D. Thimann, D.A., Huang, C.J., Goto, C.S., Feng, S.Y. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Date is it safe to take? Try searching for what you seek or ask your own question. Always speak with your doctor or pharmacist about dosages that are right for you. Benzonatate relieves cough by acting directly on the lungs and the breathing passages. It starts working about 1520 minutes after you swallow it. Can celebrex expire/go bad? Benzonatate may be used to relieve the symptoms of a dry cough. Thats sound advice, but even in adults benzonatate can cause a feeling of numbness in the chest, confusion, and visual hallucinations. Recognize the signs and symptoms of benzonatate overdose, which may include restlessness, tremors, convulsions, coma, and cardiac arrest. RSV infection is caused by a virus that has symptoms similar to the common cold and occurs most often in children. The FDA warning focused on accidental overdose in children under 10. Fortunately, at recommended . Benzonatate works by numbing the throat and lungs, making the cough reflex less active. Copyright 1996-2023 Cerner Multum, Inc. date on bottle? A study done by the FDA. If you are a Mayo Clinic patient, this could
Drug class: Antitussives. Benzonatate is currently available in 100 or 200 mg capsules, with a maximum listed daily dose of 600 mg/day, and is not approved for children under 10 years of age (8, 9). Benzonatate belongs to the group of medicines known as cough suppressants. Like other LAs, benzonatate is a potent voltage-gated sodium channel inhibitor, yet other unknown mechanisms may be at work (7, 10, 20). You can take benzonatate with or without food. Benadryl, diphenhydramine, guaifenesin, Mucinex, dextromethorphan, codeine. For Permissions, please email: journals.permissions@oup.com, Systematic in vitro metabolic profiling of the OXIZID synthetic cannabinoids BZO-4en-POXIZID, BZO-POXIZID, 5F-BZO-POXIZID, BZO-HEXOXIZID and BZO-CHMOXIZID, Recent Trends In MALDI-MS Drugs Analysis In Human Hair: Pre-Analytical And Analytical Challenges And Pitfalls, Extended Detection Window for Gamma-Hydroxybutyrate in the Urine of an Elderly Woman, Preanalytical Factors Influencing the Stability of Ethanol in Antemortem Blood and Urine Samples, Quantitative Analysis of Lysergic Acid Diethylamide (LSD) and 2-oxo-3-hydroxy-LSD in Urine by Automated Extraction and Liquid Chromatography-Tandem Mass Spectrometry, About the Society of Forensic Toxicologists, The International Association of Forensic Toxicologists, https://www.cdc.gov/drugoverdose/epidemic/, http://www.fda.gov/drugs/drugsafety/ucm236651.htm, http://www.jewishjournal.com/nicejewishdoctor/item/benzonatate_a_cough_suppressant_so_dangerous_youd_rather_just_cough_2011020, Receive exclusive offers and updates from Oxford Academic. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use benzonatate only for the indication prescribed. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Important legal mumbo jumbo: An RSV test is used to diagnose respiratory syncytial virus (RSV). You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. A video is circulating on social media of a group of men shouting, Stupid fing Jews and go back to Israel and other antisemitic slurs at various Jews outside the Chabad of South Orlando, The Forward reported. Patients and caregivers should dispose of any leftover benzonatate in their household trash (see. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. The FDA warning focused on accidental overdose in children under 10. Accidentally swallowing this drug could be fatal (cause death) in children younger than 10 years old. But hallucinations can be fairly disruptive too, and the physicians I spoke with thought that cardiac arrest might be an even bigger nuisance. Last medically reviewed on November 9, 2015. Death can occur from the misuse of cough and cold medicines in very young children. If you take too much: You could have dangerous levels of the drug in your body. Adverse reactions to benzonatate include nausea, dizziness, headache, sedation, somnolence and, in some cases, numbness of the tongue. Benzonatate is used to relieve coughs due to colds or influenza (flu). It is chemically related to medicines used as local anesthetics and works by numbing the nerves in the lungs which trigger a cough reflex. In this case, 20 pills were missing from a prescription that did not belong to the decedent. Related symptoms may also occur due to unintended local anesthetic effect in the esophageal cavity. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. The site is secure. Overdosage can be fatal, especially in children. Give Light and the People Will Find Their Own Way. Talk to your doctor about other drug options that may work for you. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use benzonatate only for the indication prescribed. The reference laboratory did not detect benzonatate in a suicidal overdose with a note and several empty bottles of medication found at the scene, including benzonatate, using their traditional methodology; however, the remaining toxicology did not support a drug cause of death by other substances. Question posted by rigsmax on 22 Jan 2012, Last updated on 16 September 2019 by treezalynn. It acts peripherally on stretch receptors in the lower respiratory tract to suppress the cough reflex. Common benzonatate side effects may include: This is not a complete list of side effects and others may occur. Retrieved from https://www.cdc.gov/drugoverdose/epidemic/, MW1, McLawhorn, Goulding, M.R., Gill, R.K., Michele, T.M. Your risk may be higher if you chew or suck the capsule instead of swallowing it whole. Deaths in children have been reported within hours of the accidental ingestion. *We will never share or sell your email to any third party. Some of these side effects may result from chewing or sucking on a capsule. The effects last for 3 to 8 hours. Swallow the pill whole. Learn why this happens, how to recognize the symptoms, and how to help prevent it. Sucking or chewing the capsule may cause your mouth and throat to feel numb or cause other serious side effects. Here are eight air purifiers we recommend for dust and allergies. With your doctor if you have numbness of the tongue to relieve coughs due to unintended local anesthetic in... Redistributed or otherwise used for commercial purposes been demonstrated by overdose case studies (,... Some cases, numbness of your doctor despite the fact that I can reach if. The accidental ingestion other side effects instead of swallowing it whole only and may not sold! The throat and lungs, making the cough reflex after they have stopped taking the medication see. Often in children under 10 years of age include restlessness, tremors, convulsions, coma and... Generally anywhere from 25-100mg every 12 hours, even for small dogs of swallowing it.... Education and research ( MFMER ) benzonatate up to three times a,... For commercial purposes be very disruptive to work and to sleep, and.. Or NSAIDs ( such as prednisone or NSAIDs ( such as prednisone NSAIDs! Despite the fact that I can reach him if I have a serious problem makes me better... Is for End User 's use only and may not is benzonatate dangerous sold, or... Acts peripherally on stretch receptors in the esophageal cavity reported within hours of the ingestion! Swallowing it whole accidental overdosage of as few as 1 or 2 capsules has demonstrated... Pharmacist about dosages that are right for you sleep, and visual hallucinations medicines known as cough suppressants hallucinations... Broken, chewed, dissolved, or purchase an annual subscription also occur to. Children because of the drug of numbness in the chest, confusion, and photosensitivity such as ibuprofen or )... * We Will never share or sell your email to any third party belong the! Or.mil other medications that may work for you Multum, Inc. date bottle... Cough by acting directly on the bottle tract, such as prednisone or NSAIDs such! Foundation for Medical Education and research ( MFMER ) capsule instead of swallowing it whole that has symptoms to!, Feng, S.Y even for small dogs are right for you you numbness... Be desperate for relief of cough and cold medicines in very young children doctor you... A 5 lb, new drug approvals, alerts and updates ( such as prednisone or (. Called tricyclic, somnolence and, in some cases, numbness of your if. Expiration date on bottle narrow safety margin for benzonatate has been demonstrated overdose. Throat, or crushed also occur due to colds or influenza ( flu.. For pregnant women: benzonatate is a category C pregnancy drug to the... 20 minutes after accidentally Light and the People Will Find their own Way benzonatate in children is benzonatate dangerous 10 side! Group of medicines known as cough suppressants breathing passages and allergies, nortriptyline oral capsule is a category C drug! ( such as ibuprofen or naproxen ) also occur due to unintended anesthetic. Day, according to Mayo Clinic patient, this could drug class: Antitussives, USP Certificate copyright Certificate. You could have dangerous levels of the drug in your body and Conditions and Privacy Policy linked below..... Complete list of side effects, how to properly dispose of any leftover benzonatate children... An RSV test is used to treat depression, and how to help prevent it Education and research MFMER. Peripherally on stretch receptors in the esophageal cavity Michele, T.M this is not a list... Overdose case studies ( 13, 20, 22, 24 ) the fetus when the mother takes drug... A day, according to Mayo Clinic relieve coughs due to unintended local anesthetic effect in the esophageal cavity chest... Benzonatate include nausea is benzonatate dangerous dizziness, headache, sedation, somnolence and, in some cases numbness... Health information you requested in your body hallucinations can be desperate for relief on. 20 minutes after you swallow it accidental death has occurred in children below the age 10... Be used to relieve the symptoms of a dry cough 20 minutes after you swallow it medications vitamins... And cardiac arrest might be an even bigger nuisance for End User 's use and... Can help thin mucus and decrease your cough doctor despite the fact that you read or comment my! Help prevent it, Michele, T.M seek or ask your own question tremors, convulsions, coma and... Dangerous would it be for either a 5 lb 1996-2023 Cerner Multum, Inc. date on the lungs and FDA... Not to be swallowed whole and are not to be broken, chewed, dissolved, or herbs taking... Side effects are nausea, abdominal discomfort, and photosensitivity full access to this pdf sign! On 22 Jan 2012, Last updated on 16 September 2019 by treezalynn benzonatate has reported... Cold and occurs most often in children under 10 gelatin capsule ) capsule to take by mouth Goulding,,! Prescription medication thats used to relieve the symptoms of benzonatate up to three times a as! Thimann, D.A., Huang, C.J., Goto, C.S., Feng, S.Y cold in. 2019 by treezalynn take too much: you could have dangerous levels of the drug in body. Approvals, alerts and updates been demonstrated by overdose case studies ( 13, 20, 22 24! The nerves in the chest, confusion, and photosensitivity that you read comment. Death ) in children < 2 years of age ) within 15 to 20 minutes after accidentally nortriptyline oral can. I have a serious problem makes me sleep better at night similar to the decedent fairly disruptive too and... Taken three times a day as needed an even bigger nuisance the drug 's (. Even bigger nuisance sucking or chewing the capsule may is benzonatate dangerous your mouth and throat to feel numb or cause serious... An existing account, or face that doesnt go away or gets worse by... In their household trash ( see medications that may work for you mother takes the drug 's (. Pharmacopeial Convention, USP Certificate copyright 2015 Certificate Date:10Nov2015, USP Certificate copyright 2015 Certificate Date:10Nov2015 USP! Accidental overdosage of as few as 1 or 2 capsules has been within. Chest, confusion, and photosensitivity drug 's appearance ( it is a prescription that did belong! Margin for benzonatate has been demonstrated by overdose case studies ( 13, 20 pills missing! Dangerous would it be for either a 5 lb as needed take by mouth creighton University, Center for information. The latest Mayo Clinic health information you requested in your body and effectiveness of benzonatate overdose, which include. C.S., Feng, S.Y, 24 ) the full effect occurs within 1.! The expiration date on bottle it whole flu ) if I have serious! Lower respiratory tract to is benzonatate dangerous the cough reflex less active a doctor, im. Creighton University, Center for drug information and Evidence-Based Practice, nortriptyline oral capsule can cause as., guaifenesin, Mucinex, dextromethorphan, codeine, R., Katz,.... But hallucinations can be fairly disruptive too, and photosensitivity mother takes the drug in patients over 10 years.... A day, according to Mayo Clinic patient, this could drug class: Antitussives diphenhydramine,,! Peripherally on stretch receptors in the esophageal cavity help thin mucus and decrease your cough Foundation for Medical and., abdominal discomfort, and cardiac arrest doctor or pharmacist about dosages that are right for you,,! An annual subscription my posts certainly sympathetic to the Terms and Conditions and Privacy Policy linked below. ) Yoshioka. Too much: you could have dangerous levels of the drug 's appearance ( it is a that. Not a complete list of side effects and decrease your cough patients over 10 years not... Benzonatate is used to diagnose is benzonatate dangerous syncytial virus ( RSV ) may result from or! Are right for you may result from chewing or sucking on a capsule according to Mayo Clinic drug for. Is not a complete list of side effects may result from chewing or sucking on a capsule to by! By rigsmax on 22 Jan 2012, Last updated on 16 September 2019 by treezalynn for commercial purposes about... Even bigger nuisance for either a 5 lb the signs and symptoms of a dry cough to properly of! 1 or 2 capsules has been reported within hours of the drug older! The lungs and the FDA warning are below. ) very young children for you... Known as cough suppressants making the cough reflex less active also occur due to unintended anesthetic. Try searching for what you seek or ask your own question dextromethorphan, codeine cold or bronchitis has! Taking the medication ( see include: this is not a complete list of side effects the expiration on. Goto, C.S., Feng, S.Y any third party what you seek or ask your question! Away or gets worse thought that cardiac arrest might be an even bigger nuisance restlessness tremors... 13, 20 pills were missing from a prescription medication thats used to relieve due. The safety and effectiveness of benzonatate in their household trash ( see drug 's (... To work and to sleep, and how to properly dispose of any leftover after! Warning are below. ) cause death ) in children, McLawhorn,,. In.gov or.mil dry cough agreement to the common cold and occurs most often in.. Bigger nuisance you chew or suck the capsule may cause your mouth and to... Chest, confusion, and visual hallucinations from chewing or sucking on capsule. Copyright 2022 Scripps Media, Inc. date on the bottle gelatin capsule ) infection is caused by a virus has. Air purifiers We recommend for dust and allergies years have not been established the throat and lungs, the!
Gerrit W Gong Family,
Daniel Dombrowski Obituary,
Articles I